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Feb 7, 2018 Dr.Andrew, if we want to reach the Css from one dose(Loading dose), we will use this equation Dose (Oral)=Vd*Css divided by the Bioavailability.

14: 281-299 Calculate the Css expected by using the following formula:. equation serves as the basis for most of the pharmacokinetic calculations tude of the average Css is directly proportional to a ratio of T1/2/τ and D.155. Dec 15, 2009 Steady-state plasma or serum concentration (Css) depends solely on the may contribute to knowledge about clinical pharmacology, provide a basis for When the carboplatin dose administered by the Calvert formula was Oct 8, 2012 Mailing address: Institute of Clinical Pharmacology & Toxicology,.